Kim, C Lee, SC Kang, SW Kwon, IC Kim, YH Jeong, SY 2024-01-21T14:04:42Z 2024-01-21T14:04:42Z 2021-09-05 2000-05-30 0743-7463 https://pubs.kist.re.kr/handle/201004/141377 Novel polymeric amphiphiles were synthesized on the basis of poly(ethylene oxide) (PEO) as a hydrophilic segment and deoxycholic acid (DC) as a hydrophobic segment. Their micellar formation and characteristics in an aqueous phase were investigated by using H-1 NMR analysis, fluorescence techniques, light scattering, and transmission electron microscopy (TEM). The PEG-DC conjugates formed micelles in the aqueous phase with critical micelle concentrations (cmc's) in the range of 36-43 mg/L at 25 degrees C. The cmc values became higher at higher temperatures. The cmc's of the conjugates were much lower than that of the deoxycholic acid sodium salts. The mean diameters of the micelles were in the range of 120-180 nm, with a narrow size distribution. The TEM image showed micelles with a spherical shape. The partition equilibrium constants, K-v, of pyrene in the micellar solutions of the PEG-DC conjugate were 1.8 x 10(4) to 7.4 x 10(4) at 25 degrees C. The K-v value decreased as the temperature increased. The steady-state fluorescence anisotropy values (r) of 1,6-diphenyl-1,3,5-hexatriene (DPH) were 0.196-0.214 in PEG-DC solutions. The anisotropy values were not significantly dependent on the length of the hydrophilic PEO block. The fluorescence lifetime values for DPH in the PEG-DC conjugate solutions were in the range of 6.05-7.03 ns, and indicated that the core region of the micelles consisted of two regions with different hydrophobicity. English AMER CHEMICAL SOC BLOCK-COPOLYMER MICELLES AMPHIPHILIC DIBLOCK COPOLYMERS POLYION COMPLEX MICELLES AQUEOUS-SOLUTION BILE-SALTS MULTIPLE MORPHOLOGIES FLUORESCENCE PROBE POLYMER MICELLES ENERGY-TRANSFER OXIDE) Synthesis and the micellar characteristics of poly(ethylene oxide)-deoxycholic acid conjugates Article 10.1021/la9907634 1 LANGMUIR, v.16, no.11, pp.4792 - 4797 LANGMUIR 16 11 4792 4797 scie scopus 000087304100008 2-s2.0-0033740505 Chemistry, Multidisciplinary Chemistry, Physical Materials Science, Multidisciplinary Chemistry Materials Science Article BLOCK-COPOLYMER MICELLES AMPHIPHILIC DIBLOCK COPOLYMERS POLYION COMPLEX MICELLES AQUEOUS-SOLUTION BILE-SALTS MULTIPLE MORPHOLOGIES FLUORESCENCE PROBE POLYMER MICELLES ENERGY-TRANSFER OXIDE) micelle poly(ethylene-oxide) deoxycholic acid conjugate