Kang, YK Shin, KJ Yoo, KH Seo, KJ Hong, CY Lee, CS Park, SY Kim, DJ Park, SW 2024-01-21T14:32:48Z 2024-01-21T14:32:48Z 2021-09-04 2000-01-17 0960-894X https://pubs.kist.re.kr/handle/201004/141618 The synthesis and biological activity of a series of new 1 beta-methylcarbapenems 1a-g containing 5'-isoxazolopyrrolidin-3'-ylthio derivatives as C-2 side chain are described. Most compounds exhibited potent and well-balanced antibacterial activity as well as high stability to DHP-1 comparable to that of meropenem. 1e and 1c showed the best combination of antibacterial activity and stability to DHP-1, respectively. (C) 2000 Elsevier Science Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD DERIVATIVES Synthesis and antibacterial activity of new carbapenems containing isoxazole moiety Article 10.1016/S0960-894X(99)00646-0 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.10, no.2, pp.95 - 99 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 10 2 95 99 scie scopus 000084969000002 2-s2.0-0002219569 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article DERIVATIVES 1β-methylcarbapenems isoxazole moiety Synthesis biological evaluation