Lee, YS Min, BJ Park, YK Lee, JY Lee, SJ Park, H 2024-01-21T14:45:07Z 2024-01-21T14:45:07Z 2021-09-05 1999-11 0040-4020 https://pubs.kist.re.kr/handle/201004/141838 A concise and efficient synthesis of tetracyclic azepino-indole derivatives 2 having a substituent at the angular position has been accomplished through an N-acyliminium ion cyclization. The coupling reaction of indol-3-yl-ethylamine 3 with 4- or 5-keto-acid 4 followed by cyclization reaction of the resulting tautomeric mixtures of keto-amide 5 and hydroxylactam 6 in refluxing formic acid provided 2. (C) 1999 Elsevier Science Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD Synthesis of angular-substituted tetracyclic azepino-indole derivatives via N-acyliminium ion cyclization Article 10.1016/S0040-4020(99)00808-X 1 TETRAHEDRON, v.55, no.45, pp.12991 - 12996 TETRAHEDRON 55 45 12991 12996 N scie scopus 000083191000007 2-s2.0-0033527803 Chemistry, Organic Chemistry Article ASYMMETRIC-SYNTHESIS ORGANOLITHIUM REAGENTS PHENETHYLSUCCINIMIDES ENANTIOMERS AFFINITY RECEPTOR DOPAMINE ACID tetracyclic azepinoindole N-acyliminium ion Keto acid hydroxylactam iminium