Kim, S Park, JH Myung, SW Lho, DS 2024-01-21T15:01:46Z 2024-01-21T15:01:46Z 2021-09-04 1999-11 0003-2654 https://pubs.kist.re.kr/handle/201004/141875 Carphedon is a phenyl derivative of nootropil and is effective in increasing physical endurance and cold resistance, and is used for amnesia treatment. Carphedon was extracted from human urine samples by solid-phase microextraction with a 65 mu m carbowax-divinylbenzene-coated fiber. This analysis was performed by using capillary gas chromatography with nitrogen-phosphorus detection and optimized at pH 9.6, 30% NaCl, immersion time 10 min and desorption in the GC injector at 250 degrees C for 3 min. The regression equation for carphedon showed good linearity in the range from 0.1 to 10 mu g ml(-1) for human urine samples. The limit of detection was 0.01 mu g ml(-1). The developed method is more sensitive and simpler in sample preparation than liquid-liquid extraction and can be applied to doping analysis for stimulants. English ROYAL SOC CHEMISTRY DRUGS Determination of carphedon in human urine by solid-phase microextraction using capillary gas chromatography with nitrogen-phosphorus detection Article 10.1039/a906027h 1 ANALYST, v.124, no.11, pp.1559 - 1562 ANALYST 124 11 1559 1562 scie scopus 000083557100005 2-s2.0-0032753303 Chemistry, Analytical Chemistry Article DRUGS bioanalysis carphedon gas chromatography SPME