Kim, NY Kang, TH Pae, HO Choi, BM Chung, HT Myung, SW Song, YS Sohn, DH Kim, YC 2024-01-21T15:03:23Z 2024-01-21T15:03:23Z 2021-09-04 1999-10 0918-6158 https://pubs.kist.re.kr/handle/201004/141900 Bioassay-guided fractionation of an aqueous extract of Alismatis Rhizoma has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, alismol (1) and alisol B monoacetate (2), together with an inactive triterpene, alisol C monoacetate (3). Compounds 1 and 2 inhibited nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS), The inhibitory effects of 1 and 2 on NO synthesis were partly due to suppression of iNOS mRNA expression as determined by Northern blotting. English PHARMACEUTICAL SOC JAPAN METHANOL EXTRACT In vitro inducible nitric oxide synthesis inhibitors from Alismatis Rhizoma Article 1 BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.22, no.10, pp.1147 - 1149 BIOLOGICAL & PHARMACEUTICAL BULLETIN 22 10 1147 1149 scie scopus 000083152600029 2-s2.0-0032735228 Pharmacology & Pharmacy Pharmacology & Pharmacy Article METHANOL EXTRACT Alismatis Rhizoma inducible nitric oxide synthase (iNOS) inhibitor RAW 264.7 cell alismol alisol B monoacetate