Roh, EJ Song, CE Kim, D Pae, HO Chung, HT Lee, KS Chai, KB Lee, CO Choi, SU 2024-01-21T15:06:44Z 2024-01-21T15:06:44Z 2021-09-05 1999-09 0968-0896 https://pubs.kist.re.kr/handle/201004/141953 The 3'-N-acyl-N-debenzoylpaclitaxel analogues 1a-d were synthesized and evaluated on biological systems. Some of the analogues 1a-d exhibited higher cytotoxicities (up to 20-fold) and stronger abilities to induce apoptosis than paclitaxel. In an in vivo experiment against ip implanted B16 melanoma, the most cytotoxic compound 1b in vitro caused tumor growth inhibition more than paclitaxel. (C) 1999 Elsevier Science Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD PROGRAMMED CELL-DEATH TAXOL ANALOGS APOPTOSIS CYTOTOXICITY MICROTUBULES CISPLATIN THERAPY CANCER LINES Synthesis and biology of 3 '-N-acyl-N-debenzoylpaclitaxel analogues Article 10.1016/S0968-0896(99)00173-X 1 BIOORGANIC & MEDICINAL CHEMISTRY, v.7, no.9, pp.2115 - 2119 BIOORGANIC & MEDICINAL CHEMISTRY 7 9 2115 2119 scie scopus 000082682500041 2-s2.0-0000086317 Biochemistry & Molecular Biology Chemistry, Medicinal Chemistry, Organic Biochemistry & Molecular Biology Pharmacology & Pharmacy Chemistry Article PROGRAMMED CELL-DEATH TAXOL ANALOGS APOPTOSIS CYTOTOXICITY MICROTUBULES CISPLATIN THERAPY CANCER LINES 3 &apos -N-acyl-N-debenzoylpaclitaxel analogues cytotoxicity apoptosis structure-activity relationship