Kang, YK Shin, KJ Yoo, KH Seo, KJ Park, SY Kim, DJ Park, SW 2024-01-21T15:08:57Z 2024-01-21T15:08:57Z 2022-01-11 1999-08-16 0960-894X https://pubs.kist.re.kr/handle/201004/141992 The synthesis and biological activity of the novel series of 1 beta-methylcarbapenems 1a-f, bearing a variety of 3 ",4 "-disubstituted pyrrolidinamides as substituents at C-2, are described. Of these carbapenems, diol 1a showed the most potent and well balanced antibacterial activity against Gram-positive and Gram-negative, 1a was also evaluated for pharmacokinetics and in vivo therapeutic efficacy in systemic infections. (C) 1999 Elsevier Science Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD CARBAPENEM ANTIBIOTICS POSITION Synthesis and biological evaluation of novel 1 beta-methylcarbapenems having a new moiety at C-2 Article 10.1016/S0960-894X(99)00407-2 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.9, no.16, pp.2385 - 2390 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 9 16 2385 2390 scie scopus 000082137300020 2-s2.0-0033575736 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article CARBAPENEM ANTIBIOTICS POSITION