Song, SC Lee, CO Sohn, YS 2024-01-21T15:11:13Z 2024-01-21T15:11:13Z 2021-09-05 1999-08 0959-8103 https://pubs.kist.re.kr/handle/201004/142032 Two different antitumour chemotherapeutic agents, doxorubicin and (dach)platinum(II) complex (dach = trans(+/-)-1,2-diaminocyclohexane) were introduced into poly(organophosphazene) using L-glutamic acid as a spacer. The resultant polymeric conjugates exhibited high in vivo antitumour activity which increased with increasing content of (dach)platinum(II) in the conjugates. The polymeric conjugate bearing 12.3 mol% of doxorubicin and 47.6 mol% of (dach)platinum(II) has shown the highest antitumour activity, which is higher than any one alone of cisplatin, carboplatin, or doxorubicin. (C) 1999 Society of Chemical Industry. English JOHN WILEY & SONS LTD MACROMOLECULAR THERAPEUTICS A novel polymeric conjugate carrying two different anticancer drugs Article 10.1002/(SICI)1097-0126(199908)48:8<627::AID-PI241>3.3.CO;2-H 1 POLYMER INTERNATIONAL, v.48, no.8, pp.627 - 629 POLYMER INTERNATIONAL 48 8 627 629 scie scopus 000081831500001 2-s2.0-0033173933 Polymer Science Polymer Science Article MACROMOLECULAR THERAPEUTICS polyphosphazene polymeric conjugate anticancer drug combination therapy