Myung, SW Min, HK Jin, C Kim, M Lee, SM Chung, GJ Park, SJ Kim, DY Cho, HW 2024-01-21T15:41:25Z 2024-01-21T15:41:25Z 2021-09-04 1999-04 0253-6269 https://pubs.kist.re.kr/handle/201004/142326 Reversed-phase high-performance liquid chromatography/mass spectrometry (HPLC/MS) with an electrospray ionization (ESI) interface was applied to the identification of metabolites of IY 81149 in the rat plasma. Fragments obtained using collision-induced dissociation (CID) in both positive and negative modes were utilized to elucidate the structure of metabolites. The eluent from the conventional HPLC column was split and directly introduced into an ESI-mass spectrometer for the identification of the structures. The CID technique allowed the sensitive identification of sulfonyl-IY81149 and hydroxy-IY81149 from the rat plasma. English PHARMACEUTICAL SOCIETY KOREA LIQUID-CHROMATOGRAPHY OMEPRAZOLE PHARMACOLOGY Identification of IY81149 and its metabolites in the rat plasma using the on-line HPLC/ESI mass spectrometry Article 10.1007/BF02976545 1 ARCHIVES OF PHARMACAL RESEARCH, v.22, no.2, pp.189 - 193 ARCHIVES OF PHARMACAL RESEARCH 22 2 189 193 scie scopus 000079751000015 2-s2.0-0033109746 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article LIQUID-CHROMATOGRAPHY OMEPRAZOLE PHARMACOLOGY IY81149 metabolites H+/K+-ATPase inhibitor HPLC electrospray ionization (ESI) mass spectrometry (MS) collision induced dissociation (CID)