Cho, YS Ha, YJ Kwon, JS Pae, AN Choi, KI Koh, HY Chang, MH Yoon, CM Lee, GS 2024-01-21T16:03:09Z 2024-01-21T16:03:09Z 2022-01-11 1999-01 0365-6233 https://pubs.kist.re.kr/handle/201004/142459 The synthesis and in vitro synergies of 2 beta-alkenyl and oxyiminopenam sulfone derivatives are described. Most of the compounds synthesized exhibited good inhibitory activities and synergistic antibacterial activities with piperacillin and ceftriaxone, respectively, against several beta-lactamase producing strains. Particularly the 2 beta-alkenylpenam sulfone derivatives, le and Ig, showed good synergistic activity with ceftriaxone against Citrobacter freundi NIH 10018-68 and Proteus vulgaris 20. Also the compounds 2a, 2c, and 2f, 2 beta-oxyiminopenam sulfone derivatives, exhibited improved synergistic activity with piperacillin against Citrobacter freundi NIH 10018-68. English WILEY-V C H VERLAG GMBH PENAM SULFONES Synthesis and evaluation of 2 beta-oxyimino and alkenylpenicillanic acid sulfone derivatives as beta-lactamase inhibitors Article 1 ARCHIV DER PHARMAZIE, v.332, no.1, pp.7 - 12 ARCHIV DER PHARMAZIE 332 1 7 12 scie scopus 000078652100002 2-s2.0-0033027188 Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy Pharmacology & Pharmacy Chemistry Article PENAM SULFONES beta-lactamase antibacterial resistances synergy effect