Lee, SB Song, SC Jin, JI Sohn, YS 2024-01-21T16:12:19Z 2024-01-21T16:12:19Z 2021-09-03 1999-01 0032-3896 https://pubs.kist.re.kr/handle/201004/142620 The antitumor platinum moiety, (dach)Pt2+ (dach = trans- (+/-)-1,2-diaminocyclohexane), was introduced to a poly(organophosphazene) using dicarboxylate spacers, glutamate or aspartate. After characterization of the polymeric conjugates by means of multinuclear (H-1, P-31) NMR spectroscopy, elemental analysis, and gel-permeation chromatography (GPC), their in vitro hydrolytic behavior was examined in buffer solutions at different pHs and temperatures by monitoring with GPC. Hydrolytic properties of the conjugates were dependent on pH and temperature of the polymer solutions, and their degradation occurred more rapidly at lower pH and higher temperature. The antitumor activity of the conjugates was evaluated both in vitro and in vivo against the murine leukemia L1210 cell line and found to be dependent on the structures of the conjugates, and some of them exhibited higher in vivo activity than cisplatin and carboplatin. English SOC POLYMER SCIENCE JAPAN CISPLATIN POLYMERS CANCER Synthesis and antitumor activity of polyphosphazene/methoxy-poly(ethylene glycol)/(diamine)platinum(II) conjugates Article 10.1295/polymj.31.1247 1 POLYMER JOURNAL, v.31, no.12, pp.1247 - 1252 POLYMER JOURNAL 31 12 1247 1252 scie scopus 000084840200011 2-s2.0-0033307311 Polymer Science Polymer Science Article CISPLATIN POLYMERS CANCER anticancer drug polymer-drug conjugates polyphosphazene methoxy-poly(ethylene glycol) (diamine)platinum(II) conjugates controlled release