Song, SC Sohn, YS 2024-01-21T16:32:39Z 2024-01-21T16:32:39Z 2021-09-03 1998-11-13 0168-3659 https://pubs.kist.re.kr/handle/201004/142732 An antitumor (diamine)platinum moiety was introduced to poly(organophosphazene) by using dicarboxylate spacers, glutamate or aspartate. A liver targeting beta-galactosyl group was also bound to 5-carboxyl-1-pentoxy residue of poly(organophosphazene) by carboxy activation with mixed anhydride method. After characterization of these polymeric conjugates by means of multinuclear (H-1, P-31) NMR and IR spectroscopies, elemental analysis and gel-permeation chromatography (GPC), their in vitro hydrolytic behavior were measured by monitoring with GPC in sodium acetate buffer solutions. Hydrolytic properties of the conjugates were dependent on pH and temperature. Over 70% of the platinum moiety was released from the conjugates after incubation for 4 days both in acidic and basic buffer solutions whereas the conjugates were stable in the neutral pH solution. (C) 1998 Elsevier Science B.V. All rights reserved. English ELSEVIER SCIENCE BV CISPLATIN POLYMERS CANCER DRUGS Synthesis and hydrolytic properties of polyphosphazene/(diamine)platinum/saccharide conjugates Article 10.1016/S0168-3659(98)00046-7 1 JOURNAL OF CONTROLLED RELEASE, v.55, no.2-3, pp.161 - 170 JOURNAL OF CONTROLLED RELEASE 55 2-3 161 170 scie scopus 000077122000006 2-s2.0-0009674418 Chemistry, Multidisciplinary Pharmacology & Pharmacy Chemistry Pharmacology & Pharmacy Article CISPLATIN POLYMERS CANCER DRUGS anticancer drug polymer-drug conjugates polyphosphazene/(diamine)platinum/saccharide conjugates controlled release targeting drug