Han, DK Park, KD Kim, YH 2024-01-21T16:41:21Z 2024-01-21T16:41:21Z 2021-09-05 1998-09 0920-5063 https://pubs.kist.re.kr/handle/201004/142882 Sulfonated poly(ethylene oxide) (PEO-SO3)-grafted polyurethane (PU) copolymer (PU-PEO-SO3) was developed for utilization as a material for biomedical applications. Its bulk properties and biocompatibility were investigated and the results were compared to those of PU and PU-PEO (not sulfonated). PU-PEO-SO3 copolymer showed higher water uptake than PU and PU-PEO, indicative of increased hydrophilicity due to the grafting of PEO-SO3. Compared with PU, PU-PEO-SO3 displayed lower glass transition temperature (T-g) and melting endotherm from DSC analysis, suggesting the increase of microphase separation and the suppression of hard-segment packing. PU-PEO-SO3 had practically similar mechanical properties to PU, indicating that the chemical modification of PU was accomplished without reducing its bulk properties. From the results of biocompatibility tests, PU-PEO-SO3 copolymer showed significantly lower adhesion of platelets and S. epidermidis than PU control and PU-PEO. In addition, the platelet factor 4 (PF4) released from platelets was the lowest in PU-PEO-SO3 among the test materials. PU-PEO-SO3 copolymer, which has excellent mechanical properties and biocompatibility, is expected to be useful as coating, molding, and blending materials for artificial organs and medical devices. English VSP BV BLOOD COMPATIBILITY ANTICOAGULANT ACTIVITY SURFACE PEO ADHESION ADSORPTION POLYMERS Sulfonated poly(ethylene oxide)-grafted polyurethane copolymer for biomedical applications Article 1 JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v.9, no.2, pp.163 - 174 JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 9 2 163 174 scie scopus 000072034800005 2-s2.0-0031984858 Engineering, Biomedical Materials Science, Biomaterials Polymer Science Engineering Materials Science Polymer Science Article BLOOD COMPATIBILITY ANTICOAGULANT ACTIVITY SURFACE PEO ADHESION ADSORPTION POLYMERS biomaterial polyurethane sulfonated PEO copolymer bulk modification biocompatibility