Jung-Ha, H Kim, D Lee, SB Hong, SI Park, SY Huh, J Kim, CW Kim, SS Lee, Y Choi, SS Shin, HS 2024-01-21T17:01:43Z 2024-01-21T17:01:43Z 2021-09-01 1998-07 0046-8177 https://pubs.kist.re.kr/handle/201004/142990 Bfl-1, a member of the Bcl-2 gene family, blocks p53-mediated apoptosis and has oncogenic transforming activity. In normal tissues, the transcript of Bfl-1 is expressed abundantly in bone marrow and at a low level in several other tissues. In previous experiments, elevated expression of Bfl-1 was observed by Northern analysis of stomach cancer samples. To study the role of Bfl-1 in normal cell development and in tumorigenesis, we have analyzed the expression of Bfl-1 in normal and tumor tissues by the in situ hybridization technique. The Bfl-1 transcript was detected in the white pulp of the spleen and in the germinal center of lymphatic tissues. In tumor tissues, its expression was preferentially detected in infiltrating inflammatory cells rather than in cancer cells, suggesting that Bfl-1 is not involved in tumorigenesis. Copyright (C) 1998 by W.B. Saunders Company. English W B SAUNDERS CO BCL-2 MESSENGER-RNA SEQUENCE SIMILARITY LYMPHOID-TISSUES GERMINAL CENTER BHRF1 PROTEIN HOMOLOG BAK B-CELLS IN-VIVO DEATH GENE Expression of Bfl-1 in normal and tumor tissues: Bfl-1 overexpression in cancer is attributable to its preferential expression in infiltrating inflammatory cells Article 10.1016/S0046-8177(98)90282-9 1 HUMAN PATHOLOGY, v.29, no.7, pp.723 - 728 HUMAN PATHOLOGY 29 7 723 728 scie scopus 000074744100010 Pathology Pathology Article BCL-2 MESSENGER-RNA SEQUENCE SIMILARITY LYMPHOID-TISSUES GERMINAL CENTER BHRF1 PROTEIN HOMOLOG BAK B-CELLS IN-VIVO DEATH GENE Bfl-1 germinal center neutrophil eosinophil tumorin-filtrating cells stomach cancer