Lee, KY Jo, WH Kwon, IC Kim, YH Jeong, SY 2024-01-21T17:09:11Z 2024-01-21T17:09:11Z 2021-09-03 1998-04-28 0743-7463 https://pubs.kist.re.kr/handle/201004/143117 Chitosan derivatives containing 2.8-5.1 deoxycholic acid groups per 100 anhydroglucosamine units of chitosan were synthesized by an EDC-mediated coupling reaction. Physicochemical properties of self-aggregates of the hydrophobically modified chitosans in aqueous media were studied by the dynamic light scattering method and fluorescence spectroscopy. The mean diameter (d(H)) of DC4.2 self-aggregates in phosphate-buffered saline (PBS) solution (pH 7.2) was 159 nm with unimodal size distribution (variance = 0.082). It seemed that the interparticle interaction between self-aggregates was almost negligible. The mean diameter decreased with increasing degree of substitution (DS), pH, or ionic strength of the medium; The critical aggregation concentration (cac) of self-aggregates was determined from the fluorescence emission spectra of pyrene. The cac value of DC4.2 in PBS solution (pH 7.2) was 2.6 x 10(-2) mg/mL. The cac values decreased with increasing DS, pH, or ionic strength of the medium. English AMER CHEMICAL SOC BLOCK COPOLYMERS MODIFIED POLYELECTROLYTES POLY(ETHYLENE OXIDE) MICELLES NANOPARTICLES SURFACTANTS POLYMERS DRUG POLYSACCHARIDES COMPLEXATION Physicochemical characteristics of self-aggregates of hydrophobically modified chitosans Article 10.1021/la970928d 1 LANGMUIR, v.14, no.9, pp.2329 - 2332 LANGMUIR 14 9 2329 2332 scie scopus 000073391300015 2-s2.0-0032047875 Chemistry, Multidisciplinary Chemistry, Physical Materials Science, Multidisciplinary Chemistry Materials Science Article BLOCK COPOLYMERS MODIFIED POLYELECTROLYTES POLY(ETHYLENE OXIDE) MICELLES NANOPARTICLES SURFACTANTS POLYMERS DRUG POLYSACCHARIDES COMPLEXATION