Choo, HYP Yoon, HR Park, HS Kim, DH Park, J Kim, J 2024-01-21T17:11:29Z 2024-01-21T17:11:29Z 2021-09-03 1998-04 0253-6269 https://pubs.kist.re.kr/handle/201004/143157 The epoxyalkanoyl derivatives were designed and synthesized as ACE inhibitors. Coupling of unsaturated carboxylic acids with amino acids and following epoxidation with dimethyldioxirane gave the epoxyalkanoyls with high yield. The inhibitory activity of synthesized compounds on angiotensin converting enzyme was IC50 values of 0.06 similar to 5.5 mu M. English PHARMACEUTICAL SOCIETY KOREA ANGIOTENSIN-CONVERTING ENZYME ANTIHYPERTENSIVE AGENTS DESIGN ACIDS Epoxyalkanoyls as novel ACE inhibitors Article 10.1007/BF02974023 1 ARCHIVES OF PHARMACAL RESEARCH, v.21, no.2, pp.168 - 173 ARCHIVES OF PHARMACAL RESEARCH 21 2 168 173 scie scopus 000073103200012 2-s2.0-0032035441 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article ANGIOTENSIN-CONVERTING ENZYME ANTIHYPERTENSIVE AGENTS DESIGN ACIDS epoxides angiotensin converting enzyme inhibitor irreversible inhibition