Park, KD Kim, YS Han, DK Kim, YH Lee, EHB Suh, H Choi, KS 2024-01-21T17:11:39Z 2024-01-21T17:11:39Z 2021-09-03 1998-04 0142-9612 https://pubs.kist.re.kr/handle/201004/143160 Polyurethane surface was modified with poly(ethylene glycol) (mol. wt. 1000, PEG1k) carrying terminal hydroxyl, amino and sulfonate groups, poly(ethylene glucol) (mol, wt. 3350, PEG3.4k) and PEG3.4k-Heparin, respectively. These surfaces were investigated for bacterial adhesion using S. epidermidis and E. coli in tryptic soya broth (TSB), brain heart infusion (BHI), and human plasma. All PEG modified surfaces reduced bacterial adhesion significantly and the adhesion level differs depending on surfaces as well as media. In the case of PEG1k surfaces, no reduction of S. epidermidis adhesion was demonstrated in TSB media, regardless of terminal functional groups of PEG1k. However, adhesion in plasma was reduced to the different degree, depending on terminal groups of PEG1k (least adhesion on sulfonated PEG surface). Relatively longer PEG surface (PEG3.4k) and PEG3.4k-heparin surface minimized bacterial adhesion in both media. In the case of E. coli adhesion, significant reduction in adherent bacteria was observed on all PEG1k, PEG3.4k, and PEG-heparin surfaces in both media compared to controls. In contrast, no reduction in bacterial adhesion was demonstrated on poly(propylene glycol) (PPG1k) grafted PU surface as compared to control PU. These results suggest that surface modification with PEG1k-SO3, PEG3.4k and PEG3.4k-heparin seems to be effective for prevention of bacterial adhesion and subsequent infection. (C) 1998 Published by Elsevier Science Ltd. All rights reserved. English ELSEVIER SCI LTD POLY(ETHYLENE OXIDE)-GRAFTED POLYURETHANE HEPARIN GRAFT-COPOLYMERS STAPHYLOCOCCUS-EPIDERMIDIS COLONIZATION INFECTION FIBRONECTIN RESISTANCE ATTACHMENT FIBRINOGEN CATHETERS Bacterial adhesion on PEG modified polyurethane surfaces Article 10.1016/S0142-9612(97)00245-7 1 BIOMATERIALS, v.19, no.7-9, pp.851 - 859 BIOMATERIALS 19 7-9 851 859 scie scopus 000074092500031 2-s2.0-0032052538 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article POLY(ETHYLENE OXIDE)-GRAFTED POLYURETHANE HEPARIN GRAFT-COPOLYMERS STAPHYLOCOCCUS-EPIDERMIDIS COLONIZATION INFECTION FIBRONECTIN RESISTANCE ATTACHMENT FIBRINOGEN CATHETERS bacterial adhesion surface modification poly(ethylene glycol) heparin