Hwang, SH Shin, KJ Kang, YK Kim, DJ Kim, DC Yoo, KH Park, SW Lee, KJ 2024-01-21T17:11:43Z 2024-01-21T17:11:43Z 2021-09-03 1998-04 0365-6233 https://pubs.kist.re.kr/handle/201004/143161 The synthesis of new 1 beta-methylcarbapenems (1a-1) having a proline reverse amide moiety at the C-2 position and their in vitro antibacterial activities are described. The compounds were evaluated by the Mueller-Hinton agar dilution method and compared with meropenem as control. Aliphatic amides (1a-h) are found to show greater antibacterial activity than aromatic amides (1i-1). Moreover, C-2 free amino compound (1m) reveals greater activity other amide compounds (1a-1). English WILEY-V C H VERLAG GMBH THIENAMYCIN ANTIBIOTICS Synthesis and antibacterial activities of new carbapenems having a proline reverse amide moiety at the C-2 position Article 10.1002/(SICI)1521-4184(199804)331:4<139::AID-ARDP139>3.0.CO;2-U 1 ARCHIV DER PHARMAZIE, v.331, no.4, pp.139 - 142 ARCHIV DER PHARMAZIE 331 4 139 142 scie scopus 000073984400004 2-s2.0-0345698874 Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy Pharmacology & Pharmacy Chemistry Article THIENAMYCIN ANTIBIOTICS 1-beta-methylcarbapenems proline reverse amide moiety antibacterial activities