Lee, SH Suh, JW Chung, BC Kim, SO 2024-01-21T17:33:34Z 2024-01-21T17:33:34Z 2021-09-05 1998-01-09 0304-3835 https://pubs.kist.re.kr/handle/201004/143290 Eleven urinary polyamine levels were determined in controls (32 cases) and 43 patients with varying stages of leukemia including initial, relapse and complete remission, using gas chromatography nitrogen-phosphorus detection. Also, to indirectly evaluate the possible involvement of enzymes, precursor to product concentration ratios were compared between controls and patients with each stage of leukemia. As a result, it is confirmed that the ratio of N-1-acSpd/N-8-acSpd could be used as a diagnostic marker and the level of N-1,N-12-diacetylspermine could be used for determining disease stage and as a malignancy marker for leukemia. An altered metabolic pathway related to leukemia is also proposed in which N-1,N-12-diacetylspermine can be produced directly from spermine and N-1,N-12-diacetylspermine is a major source of N-1-acetylspermidine. (C) 1998 Elsevier Science Ireland Ltd. English ELSEVIER SCI IRELAND LTD CANCER N-1,N-8-DIACETYLSPERMIDINE N-1,N-12-DIACETYLSPERMINE Polyamine profiles in the urine of patients with leukemia Article 10.1016/S0304-3835(97)00399-6 1 CANCER LETTERS, v.122, no.1-2, pp.1 - 8 CANCER LETTERS 122 1-2 1 8 scie scopus 000071434400001 2-s2.0-0032498255 Oncology Oncology Article CANCER N-1,N-8-DIACETYLSPERMIDINE N-1,N-12-DIACETYLSPERMINE leukemia polyamine profile gas chromatography nitrogen-phosphorus detection marker