Lee, J Lho, P Kim, M Kim, K Kim, Y 2024-01-21T17:34:12Z 2024-01-21T17:34:12Z 2022-01-11 1998-01 0951-4198 https://pubs.kist.re.kr/handle/201004/143301 Formation cyclic boronates for beta-blockers, by use of triethylamine (TEA) and pyridine as catalysts, gives more effective product: yield. Eleven beta-blockers, formed by cyclic boronation with n-butylboronic acid and TEA, produced higher yields than by on-column thermal reaction and seven beta-blockers were shown to give the highest yields in the phenyl cyclic boronation with pyridine or TEA by on-column thermal and general reaction, The phenyl cyclic boronate of nadolol produced one peak in the chromatogram and the n-butyl cyclic boronate showed two peaks. On-column derivatization with n-butylboronic acid and pyridine was effective in saving analysis time and for convenience, even though some n-butyl cyclic boronates by cyclic boronation with TEA gave a better yield, In IE-butyl cyclic boronation with pyridine by on-column thermal reaction the detection limits were 0.1 to 4 ng/mu L in urine with a signal-to-noise ratio of 10:1. (C) 1998 John Wiley & Sons, Ltd. English JOHN WILEY & SONS LTD DERIVATIVES DIOLS SEPARATION The effect of organic solvents on the determination of cyclic boronates of some beta-blockers by gas chromatography mass spectrometry Article 10.1002/(SICI)1097-0231(19980915)12:17<1150::AID-RCM282>3.3.CO;2-X 1 RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v.12, no.17, pp.1150 - 1160 RAPID COMMUNICATIONS IN MASS SPECTROMETRY 12 17 1150 1160 scie scopus 000075665000004 2-s2.0-0031659381 Biochemical Research Methods Chemistry, Analytical Spectroscopy Biochemistry & Molecular Biology Chemistry Spectroscopy Article DERIVATIVES DIOLS SEPARATION