Lee, YA Chung, YK Sohn, YS 2024-01-21T17:44:57Z 2024-01-21T17:44:57Z 2022-01-10 1997-12 0162-0134 https://pubs.kist.re.kr/handle/201004/143487 (Diamine)platinum(II) complexes of benzylmalonate derivatives as a leaving group designed in a wide range of lipophilicity and water-solubility were prepared and their antitumor activities were attempted to correlate to their lipophilicity or solubility. a good relationship was observed between their in vitro toxicity and solubility of the title complexes with the same carrier ligand, DACH (trans-(+/-)-1,2-diaminocyclohexane): The most soluble complexes are most cytoxic whereas the least soluble complexes are least cytotoxic. However, no relationship could be established between their in vivo activity and their lipophilicity or solubility presumably due to other pharmacokinetic factors involved in vivo. The molecular structure of (IPA)(2)Pt(DBM). 2CH(3)OH (IPA = isopropylamine; DBM = dibenzylmalonate) was determined by X-ray diffraction: space group P2(1)/n, a = 11.433 (3), b = 14.461 (4), c = 17.478 (4) Angstrom, beta = 97.25 (3)degrees, z = 4, R = 0.0437. (C) 1997 Elsevier Science Inc. English ELSEVIER SCIENCE INC PLATINUM(II) COMPLEXES CRYSTAL-STRUCTURES PHARMACOKINETICS LIGANDS Synthesis and antitumor activity of (diamine)platinum(II) complexes of benzylmalonate derivatives Article 10.1016/S0162-0134(97)00109-8 1 JOURNAL OF INORGANIC BIOCHEMISTRY, v.68, no.4, pp.289 - 294 JOURNAL OF INORGANIC BIOCHEMISTRY 68 4 289 294 scie scopus A1997YJ74100009 2-s2.0-0343035262 Biochemistry & Molecular Biology Chemistry, Inorganic & Nuclear Biochemistry & Molecular Biology Chemistry Article PLATINUM(II) COMPLEXES CRYSTAL-STRUCTURES PHARMACOKINETICS LIGANDS benzylmalonate