Jung, KE Kang, YK Kim, DJ Park, SW 2024-01-21T18:10:17Z 2024-01-21T18:10:17Z 2021-09-04 1997-08 0253-6269 https://pubs.kist.re.kr/handle/201004/143689 The synthesis of cis- and trans-1,6-dihydroxypyrrolizidine starting from trans-4-hydroxy-L-proline and their evaluation as glycosidase inhibitors are reported. The cis-isomer was found to be a potent inhibitor against alpha-glucosidase and showed weak inhibitory effect against other glycosidases. The trans-isomer exhibited weak inhibitions of b-glucosidase and amyloglucosidase and poor inhibition of other glycosidases. English PHARMACEUTICAL SOCIETY KOREA Synthesis and activity of a potent alpha-glucosidase inhibitor, (1R, 6R, 8S)-cis-1,6-dihydroxypyrrolizidine, and its isomer Article 10.1007/BF02976198 1 ARCHIVES OF PHARMACAL RESEARCH, v.20, no.4, pp.346 - 350 ARCHIVES OF PHARMACAL RESEARCH 20 4 346 350 N scie scopus A1997XT70700009 2-s2.0-20544461663 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article AMYLOGLUCOSIDASE MANNOSIDASE SWAINSONINE AUSTRALINE pyrrolizidine derivatives alpha-glucosidase inhibitor swainsonine