Kim, YH Han, DK Park, KD Kim, SH 2024-01-21T18:15:23Z 2024-01-21T18:15:23Z 2021-09-05 1997-06 1022-1360 https://pubs.kist.re.kr/handle/201004/143775 To improve the biocompatibility of polyurethane (PU) and bioprosthetic tissue (BT), they were chemically grafted with a hydrophilic poly(ethylene oxide) (PEO) and further negatively charged sulfonate groups (SO3) to produce PU-PEO-SO3 and BT-PEO-SO3, respectively. PU-PEO-SO3 was much more blood compatible than untreated PU and PU-PEO, and the degree of surface cracking and calcification on implanted PUs was decreased in the following order: PU > PU-PEO > PU-PEO-SO3. Also, less calcium deposition of BT-PEO-SO3 than that of BT control was observed in in vivo animal tests. Such superior blood compatibility, biostability, and anticalcification of sulfonated PEO-grafted PUs and tissues might be attributed to synergistic effects of nonadhesive and mobile PEO and negative sulfonate acid groups via a negative cilia model. English WILEY-V C H VERLAG GMBH BLOOD COMPATIBILITY POLYURETHANES CALCIFICATION Negative cilia model for biocompatibility: Sulfonated PEO-grafted polymers and tissues Article 10.1002/masy.19971180174 1 MACROMOLECULAR SYMPOSIA, v.118, pp.565 - 570 MACROMOLECULAR SYMPOSIA 118 565 570 scie scopus A1997XP30100073 2-s2.0-0031480380 Polymer Science Polymer Science Article; Proceedings Paper BLOOD COMPATIBILITY POLYURETHANES CALCIFICATION biocompatibility sulfonated PEO Negative cilia model