Woo, ER Kim, HJ Kwak, JH Lim, YK Park, SK Kim, HS Lee, CK Park, H 2024-01-21T18:40:28Z 2024-01-21T18:40:28Z 2021-09-04 1997-02 0253-6269 https://pubs.kist.re.kr/handle/201004/143970 In order to find antiviral compounds against Herpes simplex virus type I (HSV-1) and II (HSV-2) from natural products, a convenient virus-induced cytopathic effect (CPE) inhibition assay was introduced. More than 300 fractions were prepared by solvent fractionation from sixty collected plants or purchased herbal medicines, and their anti-herpetic activities were evaluated. Among them, several medicinal plants showed potent anti-herpetic activity. Selective indexes (SI) of the EtOAc extract of Caraganae Radix (Caragana sinica) against HSV-1 and HSV-2 were more than 8.06 and 24.79, SI of the MeOH extract of Acer okamotoanum leaves were 3.92 and 3.51, SI of the CH2Cl2 extract of Veratri Rhizoma et Radix (Veratrum patulum) were 5.49 and 1.31 and SI of the MeOH extract of aerial part of Osmundae Rhizoma (Osmunda japonica) were more than 3.45 and 1.25, respectively. English PHARMACEUTICAL SOCIETY KOREA Anti-herpetic activity of various medicinal plant extracts Article 10.1007/BF02974043 1 ARCHIVES OF PHARMACAL RESEARCH, v.20, no.1, pp.58 - 67 ARCHIVES OF PHARMACAL RESEARCH 20 1 58 67 N scie scopus A1997WK36600011 2-s2.0-0345719615 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article AIDS-RELATED COMPLEX PLACEBO-CONTROLLED TRIAL ZIDOVUDINE AZT AZIDOTHYMIDINE AZT HTLV-III/LAV DOUBLE-BLIND HIV INFECTION TOXICITY antivirals natural products screening herpes simplex virus type I II selective index (SI)