Kang, SB Park, S Kim, YH Kim, Y 2024-01-21T18:41:23Z 2024-01-21T18:41:23Z 2021-09-05 1997-01-01 0385-5414 https://pubs.kist.re.kr/handle/201004/143986 The benzoxazinecarboxylic acid (8), a precursor of levofloxacin (1), was prepared from (S)-2-amino-1-propanol (2) in 4 steps in good overall yield. The synthesis is characterized by one pot construction of 8 from the useful benzoylacrylates (7) which are effectively prepared in three steps. The key intermediates (7) were obtained from 2-nitrobenzoyl derivative (6a) and 2-fluorobenzoyl derivative (6b) through acylation of the acrylates (5), respectively. English PERGAMON-ELSEVIER SCIENCE LTD OPTICALLY-ACTIVE OFLOXACIN ANTIBACTERIAL ACTIVITIES DERIVATIVES AGENT ACIDS An improved synthesis of levofloxacin Article 1 HETEROCYCLES, v.45, no.1, pp.137 - 145 HETEROCYCLES 45 1 137 145 scie scopus A1997WJ19100017 2-s2.0-0003174709 Chemistry, Organic Chemistry Article OPTICALLY-ACTIVE OFLOXACIN ANTIBACTERIAL ACTIVITIES DERIVATIVES AGENT ACIDS