Chun, KH Kwon, IC Kim, YH La, SB Sohn, YT Jeong, SY 2024-01-21T19:38:30Z 2024-01-21T19:38:30Z 2021-09-05 1996-04 0253-6269 https://pubs.kist.re.kr/handle/201004/144492 Alginate microspheres were prepared by the emulsification process as a drug delivery system of ampicillin sodium (AMP-Na). The preparation parameters such as the concentration of calcium chloride, the stirring time and the amount of AMP-Na were investigated. The alginate microspheres containing hydroxypropylmethylcellulose (HPMC) were found to be generally spherical, discrete and had smoother surfaces when compared to without HPMC. However, there was no significant difference in the release profile of AMP-Na from alginate microspheres prepared with or without HPMC. The concentration of calcium chloride solution and the stirring time in the preparation of alginate microspheres influenced the aggregation of alginate microspheres. The amount of AMP-Na in alginate microspheres influenced the surface morphology and the practical drug content in microspheres. English PHARMACEUTICAL SOCIETY KOREA DRUG Preparation of sodium alginate microspheres containing hydrophilic beta-lactam antibiotics Article 10.1007/BF02976843 1 ARCHIVES OF PHARMACAL RESEARCH, v.19, no.2, pp.106 - 111 ARCHIVES OF PHARMACAL RESEARCH 19 2 106 111 scie scopus A1996UM36900005 2-s2.0-0030428920 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article DRUG microspheres sodium alginate controlled release ampicillin sodium