Lee, YA Jung, OS Kang, SJ Lee, KB Sohn, YS 2024-01-21T19:38:58Z 2024-01-21T19:38:58Z 2022-01-10 1996-03-13 0020-1669 https://pubs.kist.re.kr/handle/201004/144500 New (diamine)platinum(II) complexes A(2)PtX(2) (A(2) = trans-(+/-)-1,2-diaminocyclohexane (DACH), tetrahydro-4H-pyran-4,4-diylbis(methylamine) (THPDMA); X(2) = 9-fluorenylidenemalonate(FM), benzhydrylidenemalonate-(BHM)) have been synthesized and characterized by means of multinuclear NMR spectroscopy and X-ray analysis. (DACH)Pt(FM) crystallizes in space group P2(1)/c with eight formula units in a cell of dimensions a = 20.071(7) Angstrom, b = 12.717(3) Angstrom, c = 24.512(6) Angstrom, beta = 103.25(2)degrees, and V = 6090(3) Angstrom(3) (DACH)Pt(BHM) crystallizes in space group P (1) over bar with four molecular units in a cell of dimensions a = 11.048(3) Angstrom, b = 13.639(3) Angstrom, c = 14.043(6) Angstrom, alpha = 90.17(3)degrees, beta = 91.31(4)degrees, gamma = 89.98(3)degrees, and V = 2116(1) Angstrom(3). The platinum atom in both complexes adopts a typical square planar arrangement with two nitrogen atoms in cis position. The 9-fluorenylidene and benzhydrylidene groups of the amine ligands chelated to platinum are strikingly bent up by 88.8(3) and 80.8(2)degrees, respectively, from the platinum square plane in the solid state. Variable temperature H-1 NMR spectra of the title complexes in dimethyl sulfoxide solution reveals that the amine proton resonances are sensitive to the fluxional motion of the remote arylidene groups, and suggests that interconversion occurs between two ''bent-up'' and ''bent-down'' forms. The prominent difference between the FM and BHM complexes is observed in solution, due to the presence or absence of the angle constraint of the anionic coligands. English AMER CHEMICAL SOC PLATINUM COMPLEXES ANTITUMOR-ACTIVITY CISPLATIN ANALOGS CELL-LINES PHARMACOKINETICS Unique fluxional behavior. Synthesis, structure, and properties of novel (diamine)platinum(II) complexes of 9-fluorenylidene- and benzhydrylidenemalonate ligands Article 10.1021/ic951011+ 1 INORGANIC CHEMISTRY, v.35, no.6, pp.1641 - 1646 INORGANIC CHEMISTRY 35 6 1641 1646 scie scopus A1996UA16900038 2-s2.0-0000433399 Chemistry, Inorganic & Nuclear Chemistry Article PLATINUM COMPLEXES ANTITUMOR-ACTIVITY CISPLATIN ANALOGS CELL-LINES PHARMACOKINETICS