Yu, BG Kwon, IC Kim, YH Han, DK Park, KD Han, K Jeong, SY 2024-01-21T19:40:28Z 2024-01-21T19:40:28Z 2021-09-05 1996-03 0168-3659 https://pubs.kist.re.kr/handle/201004/144526 Fibrin glue (FG) has been successfully used in a wide range of surgical fields such as skin graft fixation, nerve repair, cartilage reattachment and microvascular anastomoses. The sustained release of antibiotics from FG for a longer period is desirable to avoid bacterial infection after application. Ampicillin sodium (AMP-Na) was selected as a model antibiotic and incorporated into FG. The incorporation of AMP-Na was attempted in two different ways. One was incorporation of AMP-Na in a dispersed state with the modification of the preparation method of FG. The other was incorporation of bovine serum albumin microspheres (BSA-MS) containing AMP-Na. The in vitro release of AMP-Na from various FGs and BSA MS was examined, The modifications of FG were found not to be appropriate methods to achieve sustained release of AMP-Na. The incorporation of crosslinked BSA-MS containing AMP-Na into FG was found to reduce the initial rapid release of AMP-Na and retarded release of AMP-Na. English ELSEVIER SCIENCE BV ADHESIVE MIXTURES INVITRO RELEASE Development of a local antibiotic delivery system using fibrin glue Article 10.1016/0168-3659(95)00139-5 1 JOURNAL OF CONTROLLED RELEASE, v.39, no.1, pp.65 - 70 JOURNAL OF CONTROLLED RELEASE 39 1 65 70 scie scopus A1996UH16500008 2-s2.0-0029933344 Chemistry, Multidisciplinary Pharmacology & Pharmacy Chemistry Pharmacology & Pharmacy Article ADHESIVE MIXTURES INVITRO RELEASE fibrin glue sustained release ampicillin sodium bovine serum albumin microsphere