Kang, IK Kwon, OH Byun, KH Kim, YH 2024-01-21T19:40:35Z 2024-01-21T19:40:35Z 2021-09-01 1996-03 0957-4530 https://pubs.kist.re.kr/handle/201004/144528 Polyetherurethaneurea (PU) films were treated by oxygen plasma discharge followed by acrylic acid (AA) grafting. The carboxyl groups of the AA-grafted PU (PU-AA) surface were coupled with bovine serum albumin and heparin via water soluble carbodiimide. Surface characterization of the modified PUs was carried out by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and electron spectroscopy for chemical analysis (ESCA). The amount of immobilized albumin and heparin on the PU surface was 1.8 and 1.5 mu g/cm(2), respectively, as determined by the dye interaction method. Interactions between the surface-modified PUs and blood components such as plasma proteins and platelets were investigated to evaluate the blood compatibility of the samples. Plasma recalcification time (PRT) and activated partial thromboplastin time (APTT) of the albumin-immobilized PU (PU-Al) were almost the same as those of PU, while platelets were less adhered on the PU-Al than on PU. On the other hand, PRT and APTT of the PU-He were significantly longer than those of the PU, PU-AA, and PU-Al. Moreover, adhesion of platelets was effectively suppressed on the PU-He, leading to good in vitro blood compatibility. English CHAPMAN HALL LTD POLYMER SURFACES GLOW-DISCHARGE PROTEINS IMMOBILIZATION POLYURETHANES ADSORPTION ADHESION CELLS FILMS Surface modification of polyetherurethaneureas and their antithrombogenicity Article 10.1007/BF00121251 1 JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v.7, no.3, pp.135 - 140 JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 7 3 135 140 scie scopus A1996UB52700002 2-s2.0-0030110375 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article POLYMER SURFACES GLOW-DISCHARGE PROTEINS IMMOBILIZATION POLYURETHANES ADSORPTION ADHESION CELLS FILMS