금교창 정용준 유은정 김병현 2024-01-21T19:41:12Z 2024-01-21T19:41:12Z 2022-01-10 1996-02 0968-0896 https://pubs.kist.re.kr/handle/201004/144538 We have developed a simple and stereoselective method for synthesizing novel dipeptide isosteres using nitrile oxide cycloaddition as a key reaction. Employing this method, we have prepared efficiently various peptidomimetics containing 2-isoxazolines and α-hydroxy ketomethylene dipeptide isosteres. English Pergamon Press Ltd. Synthesis of 2-isoxazoline and α-hydroxy ketomethylene dipeptide isosteres Article 10.1016/0968-0896(95)00174-3 1 Bioorganic and Medicinal Chemistry, v.4, no.2, pp.209 - 225 Bioorganic and Medicinal Chemistry 4 2 209 225 N scie scopus A1996UC68900006 2-s2.0-0029877105 Biochemistry & Molecular Biology Chemistry, Medicinal Chemistry, Organic Biochemistry & Molecular Biology Pharmacology & Pharmacy Chemistry Article NITRILE OXIDE CYCLOADDITIONS OPPOLZERS CHIRAL SULTAM AMINO ALDEHYDES ASYMMETRIC INDUCTION ORGANIC-SYNTHESIS PRACTICAL METHOD AIDS PEPTIDE RENIN DELTA-2-ISOXAZOLINES dipeptitde isostere peptidomimetics nitrile oxide cyclo-addition 2-isoxazoline α-hydroxy ketomethylene