Kim, JH Kwon, IC Kim, YH La, SB Sohn, YT Jeong, SY 2024-01-21T19:41:54Z 2024-01-21T19:41:54Z 2021-09-04 1996-02 0253-6269 https://pubs.kist.re.kr/handle/201004/144550 Poly (l-lactic) (PLLA) microspheres loaded with ampicillin sodium (AMP-Na), beta-lactam antibiotic, were prepared by a w/o/w multiple emulsion-solvent evaporation method. The amounts of each component in three phases (inner water phase, organic phase, and outer water phase) were carefully examined in the preparation of PLLA microspheres. The stirring rate, another preparation parameter, was also investigated for study on the effect of mechanical stress on the drug loading and morphology of PLLA microspheres. Most of the preparation parameters had a great influence on the drug loading, surface morphology and size distribution of PLLA microspheres. PLLA microspheres with 15.89 w/w% drug loading were subjected to the in vitro release experiment. The release of ampicillin sodium was constant at a rate of 1.68 mu g/ml/day per 1 mg of microspheres for 18 days after a 4 days initial burst effect. English PHARMACEUTICAL SOCIETY KOREA LOADED POLY(D,L-LACTIDE) MICROSPHERES SOLVENT EVAPORATION MICROCAPSULES ACID Preparation of biodegradable microspheres containing water-soluble drug, beta-lactam antibiotic Article 10.1007/BF02976816 1 ARCHIVES OF PHARMACAL RESEARCH, v.19, no.1, pp.30 - 35 ARCHIVES OF PHARMACAL RESEARCH 19 1 30 35 scie scopus A1996UM36800006 2-s2.0-0030428917 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article LOADED POLY(D,L-LACTIDE) MICROSPHERES SOLVENT EVAPORATION MICROCAPSULES ACID poly (l-lactic acid) microspheres (w/o/w) Emulsion solvent evaporation ampicillin sodium antibiotics