JUNG, CS LEE, SS KIM, KM JUNG, OS SOHN, YS 2024-01-21T20:32:48Z 2024-01-21T20:32:48Z 2021-09-02 1995-10-20 0253-2964 https://pubs.kist.re.kr/handle/201004/144949 New diamineplatinum(II) complexes of cyclohexylidenemalonate (chm) ligand, A(2)Pt(OOC)(2)C=C(CH2)(4)CH2 (1, A(2)=ethylenediamine (en); 2, A(2)=propylenediamine (pn); 3, A=NH3; 4, A=isopropylamine (ipa)) have been prepared. Their oxidation with H2O2 has led to the corresponding dihydroxoplatinum(IV) complexes: cis, cis, trans-A(2)Pt((OOC)2C=C (CH2)(4)CH2)(OH)(2) (5, A(2)=en; 6, A(2)=pn; 7, A=NH3; 8, A=ipa). The title complexes have been characterized by means of various spectroscopies and X-ray crystallography. 5 crystallizes in the monoclinic space group P2(1)/a (Z 4) with a=12.098(7) Angstrom, b=9.552(2) Angstrom, c 16.258(4) Angstrom, beta=98.03(5)degrees and V=1860(1) Angstrom.(3) The structure was refined to R=0.074. The local geometry around platinum atom is approximately octahedral with each hydroxide group in trans position. These platinum complexes are stable in aqueous solution. Pt(IV) complexes are readily reduced to the corresponding Pt(II) complexes by ascorbic acid. English KOREAN CHEMICAL SOC PLATINUM ANTICANCER DRUG DNA TETRAPLATIN METABOLITE REDUCTION PRODUCTS CRYSTAL SYNTHESIS AND PROPERTIES OF DIAMINEPLATINUM(II) AND DIAMINEPLATINUM(IV) COMPLEXES INVOLVING CYCLOHEXYLIDENEMALONATE LIGAND Article 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.16, no.10, pp.981 - 984 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 16 10 981 984 scie A1995TE13800018 Chemistry, Multidisciplinary Chemistry Article PLATINUM ANTICANCER DRUG DNA TETRAPLATIN METABOLITE REDUCTION PRODUCTS CRYSTAL