SONG, CE LEE, JK LEE, SH LEE, SG 2024-01-21T20:41:46Z 2024-01-21T20:41:46Z 2021-09-02 1995-05 0957-4166 https://pubs.kist.re.kr/handle/201004/145099 A new method for the preparation of (R)-carnitine (1) has been developed from enantiomerically pure (R)-4-(trichloromethyl)-oxetan-2-one [(R)-2] which was easily obtained from the [2+2]-cycloaddition of ketene and chloral in the presence of catalytic amounts of poly(acryloyl quinidine). The key intermediate, ethyl (R)-3-hydroxy-4-chlorobutyrate [(R)-5], was prepared by ethanolysis of (R)-2 followed by selective bis-dechlorination of ethyl (R)-3-hydroxy-4,4,4-trichlorobutyrate [(R)-3]. English PERGAMON-ELSEVIER SCIENCE LTD (-)-GAMMA-AMINO-BETA(R)-HYDROXYBUTYRIC ACID GABOB ASYMMETRIC-SYNTHESIS L-CARNITINE STEREOCHEMICAL CONTROL YEAST REDUCTIONS ENANTIOMERS (R)-(-)-CARNITINE RESOLUTION DISEASE NEW METHOD FOR THE PREPARATION OF (R)-CARNITINE Article 10.1016/0957-4166(95)00125-9 1 TETRAHEDRON-ASYMMETRY, v.6, no.5, pp.1063 - 1066 TETRAHEDRON-ASYMMETRY 6 5 1063 1066 scie scopus A1995RB58300013 2-s2.0-0029052235 Chemistry, Inorganic & Nuclear Chemistry, Organic Chemistry, Physical Chemistry Note (-)-GAMMA-AMINO-BETA(R)-HYDROXYBUTYRIC ACID GABOB ASYMMETRIC-SYNTHESIS L-CARNITINE STEREOCHEMICAL CONTROL YEAST REDUCTIONS ENANTIOMERS (R)-(-)-CARNITINE RESOLUTION DISEASE stereochemistry