HAN, DK LEE, NY PARK, KD KIM, YH CHO, HI MIN, BG 2024-01-21T20:43:45Z 2024-01-21T20:43:45Z 2021-09-02 1995-04 0142-9612 https://pubs.kist.re.kr/handle/201004/145133 Sulphonated poly(ethylene oxide) (PEO-SO3) and PEO-SO3-grafted polyurethane (PU-PEO-SO3) were prepared by bulk modification and their anticoagulant and heparin-like activities were investigated. Anticoagulant activity measured by activated partial thromboplastin time of PU-PEO-SO3 displayed 2%, whereas that of PEO-SO3 itself reached 14% as compared to free heparin. In addition, the anticoagulant effects of these sulphonated polymers were not due to factor Xa inhibition but mainly thrombin inhibition. From the clotting time measurements using reptilase instead of thrombin and antithrombin III (AT III), PEO-SO3 and PU-PEO-SO3 indicated heparin-like activity which represents both prolonged thrombin time (TT) and normal reptilase time and increased TT in the presence of AT III. Thrombin was also neutralized by sulphonated polymers to a great extent. Therefore, the anticoagulant and heparin-like activities of PEG-SO3 and PU-PEO-SO3 seem to contribute to their improved blood compatibility. English ELSEVIER SCI LTD BLOOD COMPATIBILITY PEO SURFACES POLYMERS HEPARIN-LIKE ANTICOAGULANT ACTIVITY OF SULFONATED POLY(ETHYLENE OXIDE) AND SULFONATED POLY(ETHYLENE OXIDE)-GRAFTED POLYURETHANE Article 10.1016/0142-9612(95)98819-Z 1 BIOMATERIALS, v.16, no.6, pp.467 - 471 BIOMATERIALS 16 6 467 471 scie scopus A1995QT55900005 2-s2.0-0029278179 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article BLOOD COMPATIBILITY PEO SURFACES POLYMERS SULFONATED PEO SULFONATED POLYURETHANES ANTICOAGULANTS HEPARIN-LIKE