KIM, YJ PARK, SJ PARK, JS LEE, W 2024-01-21T21:01:30Z 2024-01-21T21:01:30Z 2022-01-11 1995-01-06 0021-9673 https://pubs.kist.re.kr/handle/201004/145202 Benzthiazide, a banned drug in the Olympic Games, is difficult to confirm by GC-MS after methylation of urine extracts. Organic acids are added to the LC effluent to detect this drug by LC-thermospray (TSP) MS. An organic acid with a small pK(a) value is useful for detecting benzthiazide in the positive-ion mode. In the negative-ion mode, the highest sensitivity for benzthiazide was obtained by using HOCH2COOH. When LC-TSP-MS is used to detect benzthiazide, FCH2COOH and ClCH2COOH are useful organic acids in the positive-ion mode and HOCH2COOH, CH3CH2COOH and FCH2COOH in the negative-ion mode. FCH2COOH is useful in both the positive- and negative-ion modes. ClCH2COOH is a useful organic acid for detecting the molecular ion of benzthiazide. English ELSEVIER SCIENCE BV DIURETICS DETECTION OF BENZTHIAZIDE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY THERMOSPRAY MASS-SPECTROMETRY Article 10.1016/0021-9673(94)00904-N 1 JOURNAL OF CHROMATOGRAPHY A, v.689, no.1, pp.170 - 174 JOURNAL OF CHROMATOGRAPHY A 689 1 170 174 scie scopus A1995QD96800018 2-s2.0-0028800594 Biochemical Research Methods Chemistry, Analytical Biochemistry & Molecular Biology Chemistry Note DIURETICS