Lee, Y.S. Nam, K.H. CHUNG, SUN HO Park, H. 2024-01-21T21:34:46Z 2024-01-21T21:34:46Z 2021-09-02 1994-08 0039-7881 https://pubs.kist.re.kr/handle/201004/145535 An efficient and practical 8-step synthesis of enprostil (1) starting from the lactone 2 has been developed. The propargylic acetate 5 was prepared from the lactol 3 by the reaction with ethynylmagnesium bromide followed by acetylation. Propargylic acetate 5 was converted into enprostil (1) via the introduction of an allene moity by reaction with a Grignard reagent in the presence of a CuI · P(OEt)3 complex. English Georg Thieme Verlag Synthesis of prostaglandins III: Efficient and practical synthesis of antisecretory prostaglandin enprostil Article 10.1055/s-1994-25576 1 Synthesis, v.8, pp.792 - 794 Synthesis 8 792 794 N scopus 2-s2.0-0028111084 Article enprostil article drug synthesis reaction analysis allene antisecretory enprostil lactol prostaglandin