SOHN, YS KIM, KM JEONG, JH NOH, DY LEE, CO CHOI, SU 2024-01-21T21:37:41Z 2024-01-21T21:37:41Z 2022-01-11 1994-05 0162-0134 https://pubs.kist.re.kr/handle/201004/145583 1,3-Dithiol- and 1,3-dithiolan-2-ylidenemalonatoplatinum(II) complexes A(2)Pt(OOC)(2)C = CR(2) (A = NH3, cyclopropylamine (CPA) or A(2) = ethylenediamine(EDA), trans(+/-)-1,2-diaminocyclohexane(DACH); R(2) = -SCH = CHS-, -SCH2CH2S-) have been synthesized and subjected to in vivo assay for antitumor activity after characterization by means of elemental analysis, IR spectroscopy, and x-ray analysis. The molecular structure of (CPA)(2)Pt(OOC)(2)C = CSCH = CHS has been determined by x-ray diffraction: space group P2(1)/n, a = 7.955(1), b = 16.912(2), c = 15.116(2) Angstrom, beta = 102.74(1)degrees, z = 4, R = 0.032, R(w) = 0.035. Among the Pt(II) complexes studied, biscyclopropylamineplatinum(II) complexes both of the above-mentioned dicarboxylate leaving groups exhibited much higher antitumor activity against the leukemia L1210 cell line compared with the known cisplatin. English ELSEVIER SCIENCE INC SYNTHESIS, STRUCTURE, AND ANTITUMOR-ACTIVITY OF 1,3-DITHIOL AND 1,3-DITHIOLAN-2-YLIDENEMALONATOPLATINUM(II) COMPLEXES Article 10.1016/0162-0134(94)80024-3 1 JOURNAL OF INORGANIC BIOCHEMISTRY, v.54, no.2, pp.107 - 114 JOURNAL OF INORGANIC BIOCHEMISTRY 54 2 107 114 N scie scopus A1994NW05400003 2-s2.0-0028338943 Biochemistry & Molecular Biology Chemistry, Inorganic & Nuclear Biochemistry & Molecular Biology Chemistry Article PLATINUM(II) COMPLEXES CRYSTAL-STRUCTURES CIS-DICHLORODIAMMINEPLATINUM(II)