CHUNG, BC KIM, DH JUNG, BH EOM, K SLIKKER, W PARK, J 2024-01-21T21:38:23Z 2024-01-21T21:38:23Z 2021-09-01 1994-05 0049-8254 https://pubs.kist.re.kr/handle/201004/145595 1. The metabolism of pyrilamine, 2-[4-methoxybenzyl-(2-dimethylaminoelhyl) amino] pyridine, was studied in adult male volunteers after a single oral dose of 50 mg. 2. Solvent extracts of urine obtained with or without enzyme hydrolysis were analysed by gc/ms after derivatization with MSTFA/TM SCI (N-methyl-N-trimethylsilyl-trifluoroacetamidel-trimethyl chlorosilane). The structure of metabolites were determined based on EI mass spectra and confirmed with those of authentic standards. 3. Conjugated metabolites identified in the urine were pyrilamine, O-desmethylpyril amine, and ring hydroxylated derivatives of pyrilamine. O-desmethylpyrilamine was also detected in low abundance as a free form. 4. These metabolites observed in human urine were quite different from those previously reported in rat. English TAYLOR & FRANCIS LTD MALEATE ANTIHISTAMINES TRIPELENNAMINE DRUGS ASSAY RAT IDENTIFICATION OF URINARY METABOLITES OF PYRILAMINE AFTER ORAL-ADMINISTRATION TO MAN Article 10.3109/00498259409043248 1 XENOBIOTICA, v.24, no.5, pp.451 - 459 XENOBIOTICA 24 5 451 459 scie scopus A1994NN02900007 2-s2.0-0028335006 Pharmacology & Pharmacy Toxicology Pharmacology & Pharmacy Toxicology Article MALEATE ANTIHISTAMINES TRIPELENNAMINE DRUGS ASSAY RAT pyrilamine metabolite GC-MS