Lee, B.-H. Song, Y.-S. Park, J. Ryu, J.-C. 2024-01-21T22:11:00Z 2024-01-21T22:11:00Z 2021-09-02 1994-01 0253-6269 https://pubs.kist.re.kr/handle/201004/145912 The metabolism and pharmacokinetics of a mixed disulfide S-(N,N-diethyldithiocarbamoyl)-N-acetyl-L-cysteine (AC-DDTC) were studied in rats. Two metabolites of AC-DDTC following iv and po administration were identified in plasma and liver by HPLC and GC, namely N,N-diethyldithiocarbamate (DDTC) and the methyl ester of DDTC (Me-DDTC). AC-DDTC was very unstable in vivo and could not be detected neither in plasma nor in urine. Pharmacokinetic parameters of DDTC following intravenous administration of AC-DDTC (20 mg/kg) were calculated. DDTC has a low affinity to rat tissue and the total body clearance was 9.0±3.4 ml/min/kg. The mean residence time (MRT) was 111.5±16.3 min. After oral administration of 20 mg/kg AC-DDTC, maximal plasma concentration (Cmax) was 3.8±0.2 nmol/ml and the bioavailability was 7.04%. Cmax for DDTC at a dose of 120 mg/kg. AC-DDTC was 40.1±2.2 nmol/ml. MRT was 47.1±2.8 min at a dose of 20 mg/kg and 110.5±6.0 min at 120 mg/kg. ？ 1994, The Pharmaceutical Society of Korea. All rights reserved. English 5 (n,n diethyldithiocarbamoyl) n acetylcysteine unclassified drug animal experiment article controlled study drug blood level drug metabolism drug tissue level drug urine level gas chromatography high performance liquid chromatography intravenous drug administration liver nonhuman oral drug administration rat Acetylcysteine Animal Antimutagenic Agents Area Under Curve Chromatography, High Pressure Liquid Indicators and Reagents Male Rats Rats, Sprague-Dawley Support, Non-U.S. Gov&apos t Metabolism and pharmacokinetics of S-(N,N-diethyldithiocarbamoyl)-N-acetyl-L-cysteine in rats Article 10.1007/BF02979120 1 Archives of Pharmacal Research, v.17, no.6, pp.428 - 433 Archives of Pharmacal Research 17 6 428 433 scopus 2-s2.0-0028673661 Article 5 (n,n diethyldithiocarbamoyl) n acetylcysteine unclassified drug animal experiment article controlled study drug blood level drug metabolism drug tissue level drug urine level gas chromatography high performance liquid chromatography intravenous drug administration liver nonhuman oral drug administration rat Acetylcysteine Animal Antimutagenic Agents Area Under Curve Chromatography, High Pressure Liquid Indicators and Reagents Male Rats Rats, Sprague-Dawley Support, Non-U.S. Gov&apos t Disulfiram Gas Chromatography High Performance Liquid Chromatography Metabolism Mixed Disulfide Pharmacokinetics S-(N,N-diethyldithiocarbamoyl)-N-acetyl-L-cysteine