Oh, C.-H. Lee, K.-S. Roh, E.-J. Kwon, S.-K. Cho, J.-H. 2024-01-21T22:11:25Z 2024-01-21T22:11:25Z 2021-09-02 1994-01 0253-6269 https://pubs.kist.re.kr/handle/201004/145919 5-sec-Butylthiomethyl-5-alkyl (methyl or phenyl) hydantoins (3？x) were prepared by the reaction of sec-butylthiomethyl alkyl (methyl or phenyl) ketone (1？2), potassium cyanide and ammonium carbonate. 3-(2-Bromoethyl) hydantoins (5？6) were the reaction products of 5-sec-butylthiomethyl-5-alkyl (methyl or phenyl) hydantoin and 1,2-dibromoethane in the presence of potassium hydroxide. Alkylation of 5 and 6 with an excess of alkyl (methyl or ethyl) iodide in THF with sodium hydride as base gave three 1-alkyl (methyl or ethyl)-3-(2-bromoethyl) hydantoins (7？9). Treatment of the 2-bromoethyl group with potassium thioacetate and triethylamine gave three 1-alkyl (methyl or ethyl)-3-(2-acetylthioethyl) hydantoins (10？12). Hydrolysis of the 2-acetylthioethyl group with sodium hydroxide in methanol afforded the three 1-alkyl (methyl or ethyl)-3-(2-mercaptoethyl) hydantoins. ？ 1994, The Pharmaceutical Society of Korea. All rights reserved. English hydantoin derivative article drug synthesis Synthesis of new hydantoin-3-ethanethiol derivatives Article 10.1007/BF02980462 1 Archives of Pharmacal Research, v.17, no.4, pp.281 - 283 Archives of Pharmacal Research 17 4 281 283 scopus 2-s2.0-0028104757 Article hydantoin derivative article drug synthesis Analgesic activity Anti-inflammatory activity Hydantoin-3-ethanethiol Synthesis