HAN, DK RYU, GH PARK, KD JEONG, SY KIM, YH MIN, BG 2024-01-21T22:15:20Z 2024-01-21T22:15:20Z 2021-09-02 1993-10 0920-5063 https://pubs.kist.re.kr/handle/201004/145982 Fibrinogen adsorptions to surface modified polyurethanes (PU, PU-PEO, and PU-PEO-SO3) were studied from plasma in vitro. PU and PU-PEO surfaces demonstrated that initial adsorption increases with increasing plasma concentration in kinetic profiles and adsorption time in adsorption profiles as a function of plasma concentration, but after the plateau is reached, its adsorption amount decreases as plasma concentration (0.2-2.0%) and adsorption time (1-120 min) increase, respectively. In contrast, PU-PEO-SO3 showed that initial adsorption is almost same regardless of plasma concentration and adsorption time, which is due to the high affinity of surface sulfonate group to fibrinogen. All the surfaces indicated the Vroman effect at about 0.6% plasma concentration; however, the displacement was relatively low. Adsorbed amount of fibrinogen at steady state decreased in the order: PU > PU-PEO-SO3 > PU-PEO, regardless of adsorption time and plasma concentration. The adsorption behavior of PU-PEO-SO3 is attributed to both effect of low binding affinity of PEO chain and high affinity of pendant sulfonate group toward fibrinogen. English TAYLOR & FRANCIS LTD HEPARIN-IMMOBILIZED POLYURETHANES PLASMA PEO INTERFACE PROTEINS PLATELET ADSORPTION BEHAVIOR OF FIBRINOGEN TO SULFONATED POLYETHYLENEOXIDE-GRAFTED POLYURETHANE SURFACES Article 1 JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v.4, no.5, pp.401 - 413 JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 4 5 401 413 scie scopus A1993LU04000001 2-s2.0-84966131610 Engineering, Biomedical Materials Science, Biomaterials Polymer Science Engineering Materials Science Polymer Science Article HEPARIN-IMMOBILIZED POLYURETHANES PLASMA PEO INTERFACE PROTEINS PLATELET POLYURETHANES SURFACE MODIFICATION POLYETHYLENEOXIDE SULFONATE GROUP SULFONATED PEO PROTEIN ADSORPTION FIBRINOGEN