HAN, DK JEONG, SY KIM, YH MIN, BG 2024-01-21T23:38:40Z 2024-01-21T23:38:40Z 2021-09-02 1992-01 0920-5063 https://pubs.kist.re.kr/handle/201004/146701 Polyurethane (PU) surface was chemically modified by grafting of perfluorodecanoic acid (PFDA) to produce a highly hydrophobic surface to compare the blood compatability with hydrophilic poly(ethylene oxide) (PEO) grafted PUs. The advancing contact angle of modified PU-PFDA was increased up to 115 deg, while that of untreated PU was 86 deg. The PFDA grafted PU exhibited less adhesion and shape change of platelets than untreated PU, and the activated partial thromboplastin time (APTT) of PU-PFDA was considerably extended. The ex vivo occlusion time of untreated PU was only 50 min, but that of PFDA grafted PU was extended to 130 min, indicating that this hydrophobic surface is significantly blood compatible. It is interesting to find that the enhanced blood compatibility of very hydrophobic PU-PFDA was equivalent to hydrophilic PU-PEO. English VSP BV HEPARIN-IMMOBILIZED POLYURETHANES SURFACE CHARACTERISTICS AND BLOOD COMPATIBILITY OF POLYURETHANES GRAFTED BY PERFLUOROALKYL CHAINS Article 1 JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v.3, no.3, pp.229 - 241 JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 3 3 229 241 scie scopus A1992HE12200003 2-s2.0-84947372469 Engineering, Biomedical Materials Science, Biomaterials Polymer Science Engineering Materials Science Polymer Science Article HEPARIN-IMMOBILIZED POLYURETHANES POLYURETHANES, SURFACE MODIFICATION PERFLUORODECANOIC ACID GRAFTING BLOOD COMPATIBILITY HYDROPHOBILIZATION DYNAMIC CONTACT ANGLE A-A SHUNT