장인진 신재국 신상구 JJ Kim 우종인 YS Lee 박찬웅 2024-01-21T23:41:26Z 2024-01-21T23:41:26Z 2022-01-10 1991-09 0217-9687 https://pubs.kist.re.kr/handle/201004/146745 In order to evaluate the relationship between plasma nortriptyline concentration and anticholinergic effect, a single blind cross-over study of nortriptyline was performed. Seventeen healthy male volunteers were given single doses of nortriptyline (25, 50, and 75 mg) and placebo in a cross-over manner. Plasma nortriptyline concentration was measured by high performance liquid chromatography and spontaneous salivation flow was measured. Peak plasma levels of nortriptyline were attained at about 5 hours after drug administration. The corresponding area under the plasma concentration time curve (AUC) from zero-time to 12 hours after the respective dose of 25 mg, 50 mg and 75 mg nortriptyline were 87.1 ± 32.8 ng ml English SINGAPORE UNIV PRESS Assessment of the relationship between plasma nortriptyline concentration and inhibition of salivation: Single-dose study Article 1 Asia Pacific Journal of Pharmacology, v.6, no.3, pp.249 - 254 Asia Pacific Journal of Pharmacology 6 3 249 254 N scopus A1991GK92600004 2-s2.0-0026051597 Pharmacology & Pharmacy Pharmacology & Pharmacy Article nortriptyline plasma concentration salivation rate anticholinergic effect concentration-response relationship