HAN, DK JEONG, SY KIM, YH MIN, BG CHO, HI 2024-01-21T23:44:54Z 2024-01-21T23:44:54Z 2022-01-10 1991-05 0021-9304 https://pubs.kist.re.kr/handle/201004/146802 In order to investigate the interaction between various sulfonated polyurethanes (PUs) and blood, a commercial PU surface was chemically modified by poly(ethylene oxide) (PEO), dodecanediol(DDO), and propane sultone to give hydrophilic, hydrophobic, and negative sulfonated surfaces, respectively. The blood compatibility of modified PUs was evaluated by an in vitro platelet adhesion test, activated partial thromboplastin time (APTT), and prothrombin time (PT) measurements as well as an ex vivo rabbit A-A shunt method. In the platelet adhesion test, the hydrophilic PEO grafted PUs showed less platelet adhesion than untreated PU and hydrophobic DDO grafted PU. Sulfonated PU-PEO exhibited a lower degree of adhesion and shape change of platelet. The APTT and PT, especially APTT, of the sulfonated PUs were extended, whereas those of PU-PEO and PU-DDO did not show any significant change compared with untreated PU. Meanwhile, in the ex vivo experiment, hydrophilic PEO grafted PUs showed longer occlusion times than untreated PU or hydrophobic DDO grafted PU. In addition, the incorporation of SO3 groups at the end of PU-DDO and PU-PEO, particularly PU-PEO-SO3, exhibited an enormous prolongation in occlusion time, indicating a synergistic effect of the hydrophilic PEO and the negative SO3 groups on thromboresistance. These occlusion times corresponded well to in vitro evaluation results: the less adhesion and shape change of platelet and the longer APTT and PT, the more extended the ex vivo occlusion time. English JOHN WILEY & SONS INC HEPARIN-IMMOBILIZED POLYURETHANES BLOOD COMPATIBILITY SURFACES NEGATIVE CILIA CONCEPT FOR THROMBORESISTANCE - SYNERGISTIC EFFECT OF PEO AND SULFONATE GROUPS GRAFTED ONTO POLYURETHANES Article 10.1002/jbm.820250502 1 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, v.25, no.5, pp.561 - 575 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH 25 5 561 575 scie scopus A1991FG76700001 2-s2.0-0026155445 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article HEPARIN-IMMOBILIZED POLYURETHANES BLOOD COMPATIBILITY SURFACES blood compatibility grafting of sulfonated PEO polyurethane