KANG, HY PAE, AN KOH, HY CHANG, MH 2024-01-21T23:46:56Z 2024-01-21T23:46:56Z 2022-01-10 1991-02-20 0253-2964 https://pubs.kist.re.kr/handle/201004/146835 A series of compounds, N-(2-substituted-1-carboxy)vinylazetidinones were successfully synthesized in order to test the hypothesis that biological activities of beta-lactam antibiotics could be attributed to the smooth flow of electrons after a nucleophilic attack at the carbonyl carbon in the beta-lactam ring. After introduction of aminothiazolylacetamido group at 3-position of the azetidinones, their biological activities were evaluated. Their low activities led to the conclusion that the smooth electron flow in beta-lactams in not the sufficient source for the biological activities. English KOREAN CHEMICAL SOC LACTIVICIN PENEMS SYNTHESIS AND BIOLOGICAL EVALUATIONS OF N-(2-SUBSTITUTED-1-CARBOXYL) VINYLAZETIDINONES - A STUDY ON THE ESSENTIAL STRUCTURAL ELEMENT FOR BIOLOGICAL-ACTIVITIES OF BETA-LACTAM ANTIBIOTICS Article 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.12, no.1, pp.75 - 79 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 12 1 75 79 scie A1991FA54600021 Chemistry, Multidisciplinary Chemistry Article LACTIVICIN PENEMS azetidinones biological activities β -lactam antibiotics