Lho, D.-S. Hong, J.-K. Paek, H.-K. Lee, J.-A. Park, J. 2024-01-22T00:17:29Z 2024-01-22T00:17:29Z 2021-09-02 1990-04 0146-4760 https://pubs.kist.re.kr/handle/201004/147119 An analytical procedure for determination of phenolalkylamines, narcotic analgesics, and beta-blockers in urine by gas chromatography/mass spectrometry (GC/MS) is described. The detection of phenolalkylamines, narcotic analgesics, and beta-blockers is based on acid hydrolysis, liquid-liquid extraction, and selective derivatization. For screening of phenolalkylamines the m/e 179 and 267 ions were monitored by GC/MS. With narcotic analgesics, the extracted ion corresponded to the molecular ion (M +) of the drug and two additional characteristic ions. Beta-blockers were analyzed as the selectively derivatized forms of the parent molecule and its metabolltee by GC/MS with selected ion monitoring. The ions monitored for screening of betablockers containing an isopropylamine group were m/e 284 and 129 ions. The ion at m/e 86 was monitored to characterize the tert-butylamine group of beta-blockers. ？ 1990 Oxford University Press. English adrenergic receptor stimulating agent beta adrenergic receptor blocking agent doping control narcotic analgesic agent phenylalkylamine unclassified drug article doping drug determination gas chromatography human mass spectrometry methodology priority journal urine Adrenergic beta-Antagonists Analgesics, Opioid Doping in Sports Human Mass Fragmentography Substance Abuse Detection Sympathomimetics Determination of phenolalkylamines, narcotic analgesics, and beta-blockers by gas chromatography/mass spectrometry Article 10.1093/jat/14.2.77 1 Journal of Analytical Toxicology, v.14, no.2, pp.77 - 83 Journal of Analytical Toxicology 14 2 77 83 scopus 2-s2.0-0025215878 Article adrenergic receptor stimulating agent beta adrenergic receptor blocking agent doping control narcotic analgesic agent phenylalkylamine unclassified drug article doping drug determination gas chromatography human mass spectrometry methodology priority journal urine Adrenergic beta-Antagonists Analgesics, Opioid Doping in Sports Human Mass Fragmentography Substance Abuse Detection Sympathomimetics analysis phenolalkylamines narcotics beta-blockers GC GC/MS