Yoon, D.Y. Kim, J.W. Hwang, S.W. Choi, M.J. Choe, I.S. Kim, J.B. Chung, T.W. 2024-01-22T01:08:00Z 2024-01-22T01:08:00Z 2021-09-02 1989-01 0253-6269 https://pubs.kist.re.kr/handle/201004/147517 Early embryo development and implantation were arrested in ICR mice which were passively immunized with a mouse monoclonal progesterone antibody given as a single intraperitoneal injection at 12 hrs or 60 hrs post coitum (p.c.). Unimplanted embryos were recovered from the reproductive tract of the antibody-treated mice and none of these progressed to the blastocyst stage. The most pronounced effect was an arrest of embryonic development at a stage prior to cavitation. The plasma progesterone concentration in the blood taken by cardiac puncture increased greatly after the treatment by virtue of high affinity binding by the antibody in circulation. The results showed that passive immunization against progesterone shortly after mating interfered with early hormone dependent steps which were essential for normal embryonic development. ？ 1989 The Pharmaceutical Society of Korea. English Pharmaceutical Society of Korea Antifertility effect of progesterone antibodies in mice Article 10.1007/BF02911059 1 Archives of Pharmacal Research, v.12, no.4, pp.269 - 275 Archives of Pharmacal Research 12 4 269 275 N scopus 2-s2.0-51849183536 Article Antifertility passive immunization Progesterone progesterone EIA progesterone monoclonal antibodies