박기동 T. Okano C. Nojiri S. W. Kim 2024-01-22T01:12:56Z 2024-01-22T01:12:56Z 2022-01-10 1988-01 0021-9304 https://pubs.kist.re.kr/handle/201004/147598 Heparin was immobilized onto segmented polyurethane­urea surfaces (Biomer) using hydrophilic poly(ethylene oxide) spacers of different chain lengths. The use of the hydrophilic spacer, poly(ethylene oxide), reduces protein adsorption and subsequent platelet adhesion on the surface. In addition, the bioactivity of the immobilized heparin is enhanced by the incorporation of these spacers. Immobilized heparin bioactivity is shown to be a function of PEO spacer length. Use of hydrophilic PEO spacers demonstrates that immobilized heparin's bioactivity is consistently higher than that of the C English Heparin immobilization onto segmented polyurethaneurea surfaces―effect of hydrophilic spacers Article 10.1002/jbm.820221103 1 Journal of Biomedical Materials Research, v.22, no.11, pp.977 - 992 Journal of Biomedical Materials Research 22 11 977 992 N scopus 2-s2.0-0024110681