Jeon, H Blacklow, SC 2024-02-21T05:03:27Z 2024-02-21T05:03:27Z 2005 0066-4154 https://pubs.kist.re.kr/handle/201004/148759 The low-density lipoprotein receptor (LDLR) is responsible for uptake of cholesterol-carrying lipoprotein particles into cells. The receptor binds lipoprotein particles at the cell surface and releases them in the low-pH environment of the endosome. The focus of the current review is on biochemical and structural studies of the LDLR and its ligands, emphasizing how structural features of the receptor dictate the binding of low-density lipoprotein (LDL) and beta-migrating forms of very low-density lipoprotein (beta-VLDL) particles, how the receptor releases bound ligands at low pH, and how the cytoplasmic tail of the LDLR interfaces with the endocytic machinery. 2 ANNUAL REVIEWS Structure and physiologic function of the low-density lipoprotein receptor Book 10.1146/annurev.biochem.74.082803.133354 535 562