Hwang, Kyo Seon Lee, Sang-Myung Kim, Sang Kyung Lee, Jeong Hoon Kim, Tae Song 2024-02-21T05:03:30Z 2024-02-21T05:03:30Z 2009 1936-1327 https://pubs.kist.re.kr/handle/201004/148760 Recent research trends in biosensing have been geared toward developing bioanalytical devices that are label free, small in size, and portable and that can operate in a rapid manner. The performance of these devices has been dramatically improved through the advent of new materials and micro-/nanofabrication technologies. This is especially true for micro-/nanosized cantilever sensors, which undergo a change in mechanical properties upon the specific binding of biomolecules. In this review, we introduce the basic principles of cantilever biosensors in static and dynamic modes. Bale also summarize a range of approaches to cantilever design, fabrication, and instrumentation according to their applications. More specifically we describe cantilever-based detections of proteins, DNA molecules, bacteria, and viruses and discuss Current challenges related to the targets' biophysical characteristics. 2 ANNUAL REVIEWS Micro- and Nanocantilever Devices and Systems for Biomolecule Detection Book 10.1146/annurev-anchem-060908-155232 77 98